Concentrates CITRASATE®

CITRASATE® is an acidic HD concentrate that represents the first innovation in the dialysis solution since the return to haemodialysis using bicarbonate in the 80's. Citric acid is used as an acidifying agent instead of traditionally used acidic acid. It can be used for bicarbonate haemodialysis as well as on-line haemofiltration.

Benefits for dialyzed patients

significant improvement of the dialytic dose (spKt/V at 5-7%) (3,4,5)

possibility of the heparin dose reduction (2, 7, 9)

proven improvement in dialysis procedure biocompatibility (6, 8, 9)

reduced bleeding after dialysis (2)

use for specific applications (patients with HIT, contraindications to heparin, trauma) (1)

Reference

(1) Heparin Free Slow Low Efficiency Dialysis (SLED) Using Citrate Dialysate (CD) Is Safe and Effective S. Ahmad, A. Tu March 7-10, 2007, San Diego, Calif.

(2) Fifty-five Percent Heparin Reduction is Safe with Citrate Dialysate in Chronic Dialysis Patients Robert J Kossmann, MD, Robin Callan, LLM and Suhail Ahmad, MD. ASN´s 39th Annual Renal Week Meeting November 2006.

(3) Increased Efficiency of Hemodialysis with Citrate Dialysate, A Prospective Controlled Study R. J. Kossmann, A. Gonzales, R. Callan, S. Ahmad JASN Volume 4, Number 9, September 2009

(4) 4. Citrate- vs. Acetate-based Dialysate in Bicarbonate Haemodialysis: Consequences on Haemodynamics, Coagulation, Acid-base status, and Electrolytes L. Gabutti, B. Lucchini, C. Marone, L. Alberio, M. Burnier BMC Nephrology 2009, 10:7doi:10.1186/1471-2369-10-7

(5) Bikarbonátová hemodialýza s A-koncentrátem s kyselinou citrónovou (Citrasate) F. Lopot, F. Švára,V. Polakovič, Aktuality v nefrologii, 15, 2009, č. 2, 105-110

(6) Bicarbonate haemodialysis and haemodiafiltration using citric acid containing A-concentrate F. Lopot, V. Polakovič, 9th International Nephrological Symposium: Metabolic changes in chronic renal failure, Tatranská Lomnica, 21. 10. 2009 – abstrakt, Aktuality v nefrologii, 16, 2010, s. 13

(7) Dlouhodobé použití A-koncentrátu Citrasate® při bikarbonátové hemodialýze a hemodiafitraci F. Švára, V. Polakovič, F. Lopot, Český nefrologický kongres, Praha, červen 2010

(8) Higher HD/HDF efficacy with citric acid acidified-dialysate - why? V. Polakovič, B. Szonowská,F. Lopot, F. Švára, 47th ERA-EDTA Congress, 2010, abstract

(9) Dialyzační koncentrát Citraste®, In vitro testy a výsledky použití koncentrátu Citrasate® při in vivo bikarbonátové hemodialýze a on-line hemodiafiltraci V. Polakovič, F. Lopot, F. Švára, Medites Pharma, Rožnov pod Radhoštěm, 2010

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CITRASATE® is a registered trademark of the company Advanced Renal Technologies. European patent 1124567 and other requested patents.