CITRASOL

The solution determined to prevent blood coagulation during extracorporeal haemodialysis.

CITRASOL is an anticoagulant solution of sodium citrate dihydrate, determined to anticoagulation of entire blood during continual elimination methods that replace the kidney functions most of the time (Continuous Renal Replacement Therapy-CRRT). The solution is determined for aphaeresis methods.

Composition of the solution CITRASOL 4%

• The solution CITRASOL 4% contains sodium citrate dihydrate Ph. Eur.
• pH of the solution is set up using citric acid monohydrate, Ph. Eur.
• Natrii citras dihydricus 39.7 g
• Acidum citricum monohydricum 0.3 g
• Water for injections 1000 ml
• Composition in mmol/l:
• Na⁺ 404.6
• Citrates 136.4
• pH ≈ 7.0
• Theoretical osmolarity: 541 mOsm/l

Composition of the solution CITRASOL 0.5%

• The solution CITRASOL 0.5% contains sodium citrate dihydrate Ph. Eur. and sodium chloride Ph. Eur.
• pH of the solution is set up using hydrochloric acid monohydrate Ph. Eur.
• Natrii citras dihydricus 5.29 g
• Natrii chloridum 5.03 g
• Water for injections 1000 ml
• Composition in mmol/l:
• Na⁺ 140
• Citrates 18
• Chlorides 86
• pH ≈ 6.4 - 7.0
• Theoretical osmolarity: 244 mOsm/l

Advantages of the citrate anticoagulation

• The citrate is a natural metabolite that is metabolized by all tissues.
• Using citrate enables the regional (local) anticoagulant effect without the systemic anticoagulant effect.
• Local anticoagulant effect prolongs vitality of dialytic and plasma-aphaeretic filters and columns.
• It is possible to use citrate on patients with the risk of heparin induced thrombocytopenia.

CITRASOL is sterile, clear solution, free from bacterial endotoxines. It is packed in transparent, printed bags from PP (polypropylene) that are sealed in plastic overwraps (outer packing).

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Instructions for use CITRASOL 4%

Instructions for use CITRASOL 0.5%