The solution determined to prevent blood coagulation during extracorporeal haemodialysis.

CITRASOL 4% is an anticoagulant solution of 4% sodium citrate dihydrate (Natrii citras 4%), determined to anticoagulation of entire blood during continual elimination methods that replace the kidney functions most of the time (Continuous Renal Replacement Therapy-CRRT). The solution is determined for aphaeresis methods.

Composition of the solution

  • The solution CITRASOL 4% contains sodium citrate dihydrate Ph. Eur.
  • pH of the solution is set up using citric acid monohydrate, Ph. Eur.
  • Natrii citras dihydricus 39,7 g
  • Acidum citricum monohydricum 0,3 g
  • Water for injections 1000 ml
  • Composition in mmol/l
  • Na+ 404,6
  • Citrates 134,9
  • pH ≈ 7,0
  • Theoretical osmolarity: 539,5 mOsm/l

Advantages of the citrate anticoagulation

  • The citrate is a natural metabolite that is metabolized by all tissues.
  • Using citrate enables the regional (local) anticoagulant effect without the systemic anticoagulant effect.
  • Local anticoagulant effect prolongs vitality of dialytic and plasma-aphaeretic filters and columns.
  • It is possible to use citrate on patients with the risk of heparin induced thrombocytopenia.

CITRASOL 4% is sterile, clear solution, free from bacterial endotoxines. It is packed in transparent, printed bags from PP (polypropylene) that are sealed in plastic overwraps (outer packing).



Instructions for use CITRASOL 4%